CATH Classification

Domain Context

CATH Clusters

Superfamily lambda repressor-like DNA-binding domains
Functional Family (S)-2-hydroxypropylphosphonic acid epoxidase

Enzyme Information

1.11.1.23
(S)-2-hydroxypropylphosphonic acid epoxidase.
based on mapping to UniProt Q56185
(S)-2-hydroxypropylphosphonate + H(2)O(2) = (1R,2S)-1,2- epoxypropylphosphonate + 2 H(2)O.
-!- This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. -!- Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate. -!- Formerly EC 1.14.19.7.

UniProtKB Entries (1)

Q56185
HPPE_STRWE
Streptomyces wedmorensis
(S)-2-hydroxypropylphosphonic acid epoxidase

PDB Structure

PDB 2BNO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism.
Mcluskey, K., Cameron, S., Hammerschmidt, F., Hunter, W.N.
Proc.Natl.Acad.Sci.USA