CATH Domain 2bifA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

2.7.1.105	6-phosphofructo-2-kinase. based on mapping to UniProt P25114 ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.
3.1.3.46	Fructose-2,6-bisphosphate 2-phosphatase. based on mapping to UniProt P25114 Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).

UniProtKB Entries (1)

F264_RAT

Rattus norvegicus

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

PDB Structure

PDB	2BIF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Fructose 6-phosphate in the active site leads to mechanisms for both mutant and wild type bisphosphatase activities. Yuen, M.H., Mizuguchi, H., Lee, Y.H., Cook, P.F., Uyeda, K., Hasemann, C.A. J.Biol.Chem.