CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family 23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD

Enzyme Information

2.1.1.190
23S rRNA (uracil(1939)-C(5))-methyltransferase.
based on mapping to UniProt P55135
S-adenosyl-L-methionine + uracil(1939) in 23S rRNA = S-adenosyl-L- homocysteine + 5-methyluracil(1939) in 23S rRNA.
-!- The enzyme specifically methylates uracil(1939) at C(5) in 23S rRNA. -!- The enzyme contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues.

UniProtKB Entries (1)

P55135
RLMD_ECOLI
Escherichia coli K-12
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD

PDB Structure

PDB 2BH2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Unique RNA Fold in the Ruma-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function
Lee, T.T., Agarwalla, S., Stroud, R.M.
Cell(Cambridge,Mass.)