CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28511
HIR3C_HIRME
Hirudo medicinalis
Hirudin-3B'

PDB Structure

PDB 2BDY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.
Hanessian, S., Therrien, E., van Otterlo, W.A., Bayrakdarian, M., Nilsson, I., Xue, Y.
Bioorg.Med.Chem.Lett.