CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P12931
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P12931
SRC_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 2BDF
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Dalgarno, D., Stehle, T., Narula, S., Schelling, P., van Schravendijk, M.R., Adams, S., Andrade, L., Keats, J., Ram, M., Jin, L., Grossman, T., MacNeil, I., Metcalf III, C., Shakespeare, W., Wang, Y., Keenan, T., Sundaramoorthi, R., Bohacek, R., Weigele, M., Sawyer, T.
Chem.Biol.Drug Des.