CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.325 |
Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).
based on mapping to UniProt Q8KES3
(1) L-threo-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH.
-!- This enzyme, isolated from the bacterium Chlorobium tepidum, catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- Cf. EC 1.1.1.153.
|
UniProtKB Entries (1)
| Q8KES3 |
SPRE_CHLTE
Chlorobaculum tepidum TLS
Sepiapterin reductase
|
PDB Structure
| PDB | 2BD0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
J.Biol.Chem.
|