CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.6.99.3
NADH dehydrogenase.
based on mapping to UniProt Q5XC60
NADH + acceptor = NAD(+) + reduced acceptor.
-!- After preparations have been subjected to certain treatments cytochrome c may act as acceptor. -!- Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. -!- Present in a mitochondrial complex as EC 7.1.1.2. -!- Formerly EC 1.6.2.1.

UniProtKB Entries (1)

Q5XC60
NAOX_STRP6
Streptococcus pyogenes MGAS10394
Probable NADH oxidase

PDB Structure

PDB 2BCP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate.
Wallen, J.R., Mallett, T.C., Okuno, T., Parsonage, D., Sakai, H., Tsukihara, T., Claiborne, A.
Biochemistry