CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.287.1270
Functional Family

Enzyme Information

2.7.11.15
[Beta-adrenergic-receptor] kinase.
based on mapping to UniProt P21146
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
-!- Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. -!- Does not act on casein or histones. -!- Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16). -!- Formerly EC 2.7.1.126.

UniProtKB Entries (2)

P21279
GNAQ_MOUSE
Mus musculus
Guanine nucleotide-binding protein G(q) subunit alpha
P63212
GBG2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

PDB Structure

PDB 2BCJ
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Tesmer, V.M., Kawano, T., Shankaranarayanan, A., Kozasa, T., Tesmer, J.J.G.
Science