CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 2B8L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Conformationally biased P3 amide replacements of beta-secretase inhibitors
Stachel, S.J., Coburn, C.A., Steele, T.G., Crouthamel, M.C., Pietrak, B.L., Lai, M.T., Holloway, M.K., Munshi, S.K., Graham, S.L., Vacca, J.P.
Bioorg.Med.Chem.Lett.