CATH Domain 2b8hA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt P05803

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P05803

NRAM_I84A1

Influenza A virus (A/whale/Maine/1/84(H13N9))

Neuraminidase

PDB Structure

PDB	2B8H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Gallus
Primary Citation	Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding. Smith, B.J., Huyton, T., Joosten, R.P., McKimm-Breschkin, J.L., Zhang, J.G., Luo, C.S., Lou, M.Z., Labrou, N.E., Garrett, T.P. Acta Crystallogr.,Sect.D