CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.80
Isopropanol dehydrogenase (NADP(+)).
based on mapping to UniProt P25984
Propan-2-ol + NADP(+) = acetone + NADPH.
-!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.

UniProtKB Entries (1)

P25984
ADH_CLOBE
Clostridium beijerinckii
NADP-dependent isopropanol dehydrogenase

PDB Structure

PDB 2B83
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.
Goihberg, E., Dym, O., Tel-Or, S., Levin, I., Peretz, M., Burstein, Y.
Proteins