CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P84786
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P84786
RIP_DRIMA
Drimia maritima
Ribosome-inactivating protein charybdin

PDB Structure

PDB 2B7U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Isolation, characterization, sequencing and crystal structure of charybdin, a type 1 ribosome-inactivating protein from Charybdis maritima agg.
Touloupakis, E., Gessmann, R., Kavelaki, K., Christofakis, E., Petratos, K., Ghanotakis, D.F.
Febs J.