CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Fumarate reductase flavoprotein subunit

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0A8Q0
FRDC_ECOLI
Escherichia coli K-12
Fumarate reductase subunit C

PDB Structure

PDB 2B76
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Fumarate Reductase and Succinate Oxidase Activity of Escherichia coli Complex II Homologs Are Perturbed Differently by Mutation of the Flavin Binding Domain
Maklashina, E., Iverson, T.M., Sher, Y., Kotlyar, V., Andrell, J., Mirza, O., Hudson, J.M., Armstrong, F.A., Rothery, R.A., Weiner, J.H., Cecchini, G.
J.Biol.Chem.