CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 1.3.98.1 |
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q57U83
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.
|
UniProtKB Entries (1)
| Q57U83 |
PYRD_TRYB2
Trypanosoma brucei brucei TREU927
Dihydroorotate dehydrogenase (fumarate)
|
PDB Structure
| PDB | 2B4G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol.
|