CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Release factor glutamine methyltransferase

Enzyme Information

2.1.1.297
Peptide chain release factor N(5)-glutamine methyltransferase.
based on mapping to UniProt P0ACC1
S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L- glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.
-!- Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity. -!- Formerly EC 2.1.1.n16.

UniProtKB Entries (1)

P0ACC1
PRMC_ECOLI
Escherichia coli K-12
Release factor glutamine methyltransferase

PDB Structure

PDB 2B3T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular basis for bacterial class I release factor methylation by PrmC
Graille, M., Heurgue-Hamard, V., Champ, S., Mora, L., Scrima, N., Ulryck, N., van Tilbeurgh, H., Buckingham, R.H.
Mol.Cell