CATH Classification

Domain Context

CATH Clusters

Superfamily Methylglyoxal synthase-like domain
Functional Family

Enzyme Information

3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt P31335
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31335
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

P31335
PUR9_CHICK
Gallus gallus
Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB 2B1G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
J.Biol.Chem.