CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14757
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757
CHK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk1

PDB Structure

PDB 2AYP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors
Lin, N.-H., Xia, P., Kovar, P., Park, C., Chen, Z., Zhang, H., Rosenberg, S.H., Sham, H.L.
Bioorg.Med.Chem.Lett.