CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Malic enzyme |
Enzyme Information
| 1.1.1.40 |
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
based on mapping to UniProt P48163
(1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2).
-!- The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.
|
UniProtKB Entries (1)
| P48163 |
MAOX_HUMAN
Homo sapiens
NADP-dependent malic enzyme
|
PDB Structure
| PDB | 2AW5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of a human malic enzyme
To be published
|