CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P0ABQ4
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P0ABQ4
DYR_ECOLI
Escherichia coli K-12
Dihydrofolate reductase

PDB Structure

PDB 2ANO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region
Summerfield, R.L., Daigle, D.M., Mayer, S., Mallik, D., Hughes, D.W., Jackson, S.G., Sulek, M., Organ, M.G., Brown, E.D., Junop, M.S.
J.Med.Chem.