CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P55859
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P55859
PNPH_BOVIN
Bos taurus
Purine nucleoside phosphorylase

PDB Structure

PDB 2AI2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Toms, A.V., Wang, W., Li, Y., Ganem, B., Ealick, S.E.
Acta Crystallogr.,Sect.D