CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family Glutaminyl-peptide cyclotransferase

Enzyme Information

2.3.2.5
Glutaminyl-peptide cyclotransferase.
based on mapping to UniProt Q16769
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
-!- Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. -!- The enzyme from papaya also acts on glutaminyl-tRNA.

UniProtKB Entries (1)

Q16769
QPCT_HUMAN
Homo sapiens
Glutaminyl-peptide cyclotransferase

PDB Structure

PDB 2AFU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Huang, K.F., Liu, Y.L., Cheng, W.J., Ko, T.P., Wang, A.H.
Proc.Natl.Acad.Sci.Usa