CATH Classification

Domain Context

CATH Clusters

Superfamily RlpA-like domain
Functional Family Membrane-bound lytic murein transglycosylase A

Enzyme Information

4.2.2.n1
Peptidoglycan lytic exotransglycosylase.
based on mapping to UniProt P0A935
Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0A935
MLTA_ECOLI
Escherichia coli K-12
Membrane-bound lytic murein transglycosylase A

PDB Structure

PDB 2AE0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of MltA from Escherichia coli Reveals a Unique Lytic Transglycosylase Fold
van Straaten, K.E., Dijkstra, B.W., Vollmer, W., Thunnissen, A.M.W.H.
J.Mol.Biol.