CATH Classification

Domain Context

CATH Clusters

Superfamily Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2
Functional Family

Enzyme Information

2.1.1.72
Site-specific DNA-methyltransferase (adenine-specific).
based on mapping to UniProt P14385
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P14385
MTTA_THEAQ
Thermus aquaticus
Modification methylase TaqI

PDB Structure

PDB 2ADM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
Schluckebier, G., Kozak, M., Bleimling, N., Weinhold, E., Saenger, W.
J.Mol.Biol.