CATH Classification

Domain Context

CATH Clusters

Superfamily succinate dehydrogenase protein domain
Functional Family Succinate dehydrogenase flavoprotein subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt P0AC41
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P07014
SDHB_ECOLI
Escherichia coli K-12
Succinate dehydrogenase iron-sulfur subunit

PDB Structure

PDB 2ACZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.
Horsefield, R., Yankovskaya, V., Sexton, G., Whittingham, W., Shiomi, K., Omura, S., Byrne, B., Cecchini, G., Iwata, S.
J.Biol.Chem.