CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1400
Functional Family Ferrochelatase

Enzyme Information

4.99.1.1
Protoporphyrin ferrochelatase.
based on mapping to UniProt P32396
Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
-!- The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.

UniProtKB Entries (1)

P32396
HEMH_BACSU
Bacillus subtilis subsp. subtilis str. 168
Ferrochelatase

PDB Structure

PDB 2AC2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Metallation of the Transition-state Inhibitor N-methyl Mesoporphyrin by Ferrochelatase: Implications for the Catalytic Reaction Mechanism.
Shipovskov, S., Karlberg, T., Fodje, M., Hansson, M.D., Ferreira, G.C., Hansson, M., Reimann, C.T., Al-Karadaghi, S.
J.Mol.Biol.