CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q27743
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q27743
LDH_PLAFD
Plasmodium falciparum CDC/Honduras
L-lactate dehydrogenase

PDB Structure

PDB 2A94
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH.
Chaikuad, A., Fairweather, V., Conners, R., Joseph-Horne, T., Turgut-Balik, D., Brady, R.L.
Biochemistry