CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase Rpb2, domain 2
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SHR6
RPOA_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 2A68
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G.
Cell(Cambridge,Mass.)