CATH Classification

Domain Context

CATH Clusters

Superfamily Carbonic anhydrase
Functional Family Carbonic anhydrase

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P9WPJ9
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P9WPJ9
MTCA2_MYCTU
Mycobacterium tuberculosis H37Rv
Carbonic anhydrase 2

PDB Structure

PDB 2A5V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Mechanics of the pH-dependent Activity of beta-Carbonic Anhydrase from Mycobacterium tuberculosis
Covarrubias, A.S., Bergfors, T., Jones, T.A., Hogbom, M.
J.Biol.Chem.