CATH Classification

Domain Context

CATH Clusters

Superfamily 6.20.120.40
Functional Family

Enzyme Information

5.4.3.2
Lysine 2,3-aminomutase.
based on mapping to UniProt Q9XBQ8
L-lysine = (3S)-3,6-diaminohexanoate.
-!- This enzyme is a member of the 'AdoMet radical' (radical SAM) family. -!- It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. -!- Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. -!- A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron- sulfur cluster. -!- S-adenosyl-L-methionine is regenerated at the end of the reaction.

UniProtKB Entries (1)

Q9XBQ8
KAMA_CLOSU
Clostridium subterminale
L-lysine 2,3-aminomutase

PDB Structure

PDB 2A5H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale.
Lepore, B.W., Ruzicka, F.J., Frey, P.A., Ringe, D.
Proc.Natl.Acad.Sci.Usa