CATH Classification

Domain Context

CATH Clusters

Superfamily Endonuclease/exonuclease/phosphatase
Functional Family Deoxyribonuclease

Enzyme Information

3.1.21.1
Deoxyribonuclease I.
based on mapping to UniProt P00639
Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.
-!- Preference for double-stranded DNA. -!- Similar enzymes: streptococcal DNase (streptodornase), T4 endonuclease II, T7 endonuclease II, Escherichia coli endonuclease I, 'nicking' nuclease of calf thymus, colicin E2 and E3. -!- Formerly EC 3.1.4.5.

UniProtKB Entries (3)

P68135
ACTS_RABIT
Oryctolagus cuniculus
Actin, alpha skeletal muscle
P00639
DNAS1_BOVIN
Bos taurus
Deoxyribonuclease-1
O43516
WIPF1_HUMAN
Homo sapiens
WAS/WASL-interacting protein family member 1

PDB Structure

PDB 2A41
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Chereau, D., Kerff, F., Graceffa, P., Grabarek, Z., Langsetmo, K., Dominguez, R.
Proc.Natl.Acad.Sci.Usa