CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Eukaryotic translation initiation factor 2-alpha kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P19525
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P19525
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P19525
E2AK2_HUMAN
Homo sapiens
Interferon-induced, double-stranded RNA-activated protein kinase
P20459
IF2A_YEAST
Saccharomyces cerevisiae S288C
Eukaryotic translation initiation factor 2 subunit alpha

PDB Structure

PDB 2A1A
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Dar, A.C., Dever, T.E., Sicheri, F.
Cell(Cambridge,Mass.)