CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease III domain
Functional Family Ribonuclease 3

Enzyme Information
Ribonuclease III.
based on mapping to UniProt P9WH03
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

Mycobacterium tuberculosis H37Rv
Ribonuclease 3

PDB Structure

PDB 2A11
External Links
Organism Escherichia
Primary Citation
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A
Akey, D.L., Berger, J.M.
Protein Sci.