CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphohistidine domain
Functional Family Phosphoenolpyruvate-protein phosphotransferase

Enzyme Information

2.7.3.9
Phosphoenolpyruvate--protein phosphotransferase.
based on mapping to UniProt P08839
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.
-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.

UniProtKB Entries (1)

P08839
PT1_ECOLI
Escherichia coli K-12
Phosphoenolpyruvate-protein phosphotransferase

PDB Structure

PDB 1ZYM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr.
Liao, D.I., Silverton, E., Seok, Y.J., Lee, B.R., Peterkofsky, A., Davies, D.R.
Structure