CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family eIF-2-alpha kinase GCN2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P15442
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15442
GCN2_YEAST
Saccharomyces cerevisiae S288C
EIF-2-alpha kinase GCN2

PDB Structure

PDB 1ZY5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
Padyana, A.K., Qiu, H., Roll-Mecak, A., Hinnebusch, A.G., Burley, S.K.
J.Biol.Chem.