CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB 1ZXC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Levin, J.I., Chen, J.M., Laakso, L.M., Du, M., Du, X., Venkatesan, A.M., Sandanayaka, V., Zask, A., Xu, J., Xu, W., Zhang, Y., Skotnicki, J.S.
Bioorg.Med.Chem.Lett.