CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P03951
FA11_HUMAN
Homo sapiens
Coagulation factor XI

PDB Structure

PDB 1ZRK
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series
Guo, Z., Bannister, T., Noll, R., Jin, L., Rynkiewicz, M.J., Bibbins, F., Magee, S., Gorga, J., Babine, R., Strickler, J.
To be Published