CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Cationic trypsin

Enzyme Information

3.4.21.4
Trypsin.
based on mapping to UniProt P00760
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P00760
TRY1_BOVIN
Bos taurus
Cationic trypsin
P48307
TFPI2_HUMAN
Homo sapiens
Tissue factor pathway inhibitor 2

PDB Structure

PDB 1ZR0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition
Schmidt, A.E., Chand, H.S., Cascio, D., Kisiel, W., Bajaj, S.P.
J.Biol.Chem.