CATH Classification

Domain Context

CATH Clusters

Superfamily Formyl transferase, N-terminal domain
Functional Family Trifunctional purine biosynthetic protein adenosine-3

Enzyme Information

2.1.2.2
Phosphoribosylglycinamide formyltransferase.
based on mapping to UniProt P22102
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
6.3.4.13
Phosphoribosylamine--glycine ligase.
based on mapping to UniProt P22102
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide.
-!- Formerly EC 6.3.1.3.
6.3.3.1
Phosphoribosylformylglycinamidine cyclo-ligase.
based on mapping to UniProt P22102
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

UniProtKB Entries (1)

P22102
PUR2_HUMAN
Homo sapiens
Trifunctional purine biosynthetic protein adenosine-3

PDB Structure

PDB 1ZLX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.
Dahms, T.E., Sainz, G., Giroux, E.L., Caperelli, C.A., Smith, J.L.
Biochemistry