CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase E

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62937
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62937
PPIA_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB 1ZKF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mechanistic Insights of Cyclophilin-A from X-Ray Cyrstallographic and Nuclear Magnet Resonance Investigations
Eisenmesser, E.Z., Thai, V., Pozharski, E., Kern, D.
To be Published