CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P24327
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P24327
PRSA_BACSU
Bacillus subtilis subsp. subtilis str. 168
Foldase protein PrsA

PDB Structure

PDB 1ZK6
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
NMR solution structure and characterization of substrate binding site of the PPIase domain of PrsA protein from Bacillus subtilis
Tossavainen, H., Permi, P., Purhonen, S.L., Sarvas, M., Kilpelainen, I., Seppala, R.
Febs Lett.