CATH Classification

Domain Context

CATH Clusters

Superfamily Hedgehog/Intein (Hint) domain
Functional Family

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P74750
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P74750
DPO3A_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
DNA polymerase III subunit alpha

PDB Structure

PDB 1ZD7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of an intein from the split dnaE gene of Synechocystis sp. PCC6803 reveal the catalytic model without the penultimate histidine and the mechanism of zinc ion inhibition of protein splicing
Sun, P., Ye, S., Ferrandon, S., Evans, T.C., Xu, M.Q., Rao, Z.
J.Mol.Biol.