CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C15, pyroglutamyl peptidase I-like
Functional Family Pyrrolidone-carboxylate peptidase

Enzyme Information

3.4.19.3
Pyroglutamyl-peptidase I.
based on mapping to UniProt O73944
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
-!- Removes 5-oxoproline from various penultimate amino acid residues except L-proline. -!- Inhibited by thiol-blocking reagents. -!- Belongs to peptidase family C15. -!- Formerly EC 3.4.11.8.

UniProtKB Entries (1)

O73944
PCP_PYRFU
Pyrococcus furiosus DSM 3638
Pyrrolidone-carboxylate peptidase

PDB Structure

PDB 1Z8X
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Completely buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles.
Kaushik, J.K., Iimura, S., Ogasahara, K., Yamagata, Y., Segawa, S., Yutani, K.
Biochemistry