CATH Classification

Domain Context

CATH Clusters

Superfamily UDP-galactose 4-epimerase, domain 1
Functional Family

Enzyme Information

1.1.1.305
UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating).
based on mapping to UniProt P77398
UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentapyranos-4-ulose + CO(2) + NADH.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13. -!- Formerly EC 1.1.1.n1.
2.1.2.13
UDP-4-amino-4-deoxy-L-arabinose formyltransferase.
based on mapping to UniProt P77398
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305. -!- Formerly EC 2.1.2.n1.

UniProtKB Entries (1)

P77398
ARNA_ECOLI
Escherichia coli K-12
Bifunctional polymyxin resistance protein ArnA

PDB Structure

PDB 1Z7B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance
Gatzeva-Topalova, P.Z., May, A.P., Sousa, M.C.
Structure