CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P20429
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P20429
RPOA_BACSU
Bacillus subtilis subsp. subtilis str. 168
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 1Z3E
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the {alpha} C-terminal domain of RNA polymerase
Newberry, K.J., Nakano, S., Zuber, P., Brennan, R.G.
Proc.Natl.Acad.Sci.Usa