1 keywords

CATH Domain 1z1lA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt O00408
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

O00408
PDE2A_HUMAN
Homo sapiens
CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 1Z1L
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural Determinants for Inhibitor Specificity and Selectivity in PDE2A Using the Wheat Germ in Vitro Translation System.
Iffland, A., Kohls, D., Low, S., Luan, J., Zhang, Y., Kothe, M., Cao, Q., Kamath, A.V., Ding, Y.H., Ellenberger, T.
Biochemistry