CATH Classification

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family Ketol-acid reductoisomerase

Enzyme Information

1.1.1.86
Ketol-acid reductoisomerase.
based on mapping to UniProt P05793
(1) (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

P05793
ILVC_ECOLI
Escherichia coli K-12
Ketol-acid reductoisomerase

PDB Structure

PDB 1YRL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution
Tyagi, R., Duquerroy, S., Navaza, J., Guddat, L.W., Duggleby, R.G.
Protein Sci.