CATH Classification

Domain Context

CATH Clusters

Superfamily Single helix bin
Functional Family Mitochondrial succinate dehydrogenase cytochrome b560 subunit

Enzyme Information
Succinate dehydrogenase (quinone).
based on mapping to UniProt D0VWW3
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC

UniProtKB Entries (1)

Gallus gallus
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

PDB Structure

External Links
Primary Citation
3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme
Huang, L., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A.