CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28504
HIR2_HIRME
Hirudo medicinalis
Hirudin-2

PDB Structure

PDB 1YPM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and X-ray crystal structures of human thrombin with synthetic cyanopeptide-analogues.
Radau, G., Fokkens, J.
Pharmazie