CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.100
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q9KWU7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q9KWU8
RPOA_THEAQ
Thermus aquaticus
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 1YNJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Embo J.