CATH Classification

Domain Context

CATH Clusters

Superfamily NADH Oxidase
Functional Family Oxygen-insensitive NAD(P)H nitroreductase

Enzyme Information

1.5.1.34
6,7-dihydropteridine reductase.
based on mapping to UniProt P38489
A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
-!- The substrate is the quinonoid form of dihydropteridine. -!- Not identical with EC 1.5.1.3. -!- Formerly EC 1.6.99.7 and EC 1.6.99.10.
1.-.-.-
Oxidoreductases.
based on mapping to UniProt P38489

UniProtKB Entries (1)

P38489
NFSB_ECOLI
Escherichia coli K-12
Oxygen-insensitive NAD(P)H nitroreductase

PDB Structure

PDB 1YKI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
Race, P.R., Lovering, A.L., Green, R.M., Ossor, A., White, S.A., Searle, P.F., Wrighton, C.J., Hyde, E.I.
J.Biol.Chem.